ctcRbase

Entry Detail

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General Information

Database ID: SKCM04744 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: KIAA0556 Full Name: KIAA0556 Category: mRNA Synonyms: JBTS26 Chromosome: chr16 Strand: + Coordinate: Start Site(bp): 27550133 End Site(bp): 27780369 Gene Summary: This gene encodes a novel, evolutionarily conserved, ciliary protein. In human hTERT-RPE1 cells, the protein is found at the base of cilia, decorating the ciliary axoneme, and enriched at the ciliary tip. The protein binds to microtubules in vitro and regulates their stability when it is overexpressed. A null mutation in this gene has been associated with Joubert syndrome, a recessive disorder that is characterized by a distinctive mid-hindbrain and cerebellar malformation and is also often associated with wider ciliopathy symptoms. Consistently, in a serum-starvation ciliogenesis assay, human fibroblast cells derived from patients with the mutation display a reduced number of ciliated cells with abnormally long cilia. [provided by RefSeq, Feb 2016] External Links: Ensembl ID: ENSG00000047578 HGNC ID: HGNC:29068 Entrez Gene: 23247

Expression Profile of KIAA0556 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-124-3p YES NO YES hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-144-3p YES NO YES hsa-miR-153-3p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-22-3p YES NO YES hsa-miR-25-3p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-448 YES NO YES hsa-miR-486-5p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-615-3p YES NO YES hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: