ctcRbase

Entry Detail

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General Information

Database ID: SKCM04763 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GLE1 Full Name: GLE1, RNA export mediator Category: mRNA Synonyms: GLE1L|LCCS|LCCS1|hGLE1 Chromosome: chr9 Strand: + Coordinate: Start Site(bp): 128504700 End Site(bp): 128542288 Gene Summary: This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000119392 HGNC ID: HGNC:4315 Entrez Gene: 2733

Expression Profile of GLE1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-326 YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-503-5p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-876-5p YES YES NO hsa-miR-96-5p YES YES YES Display: