ctcRbase

Entry Detail

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General Information

Database ID: SKCM04803 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: FGD4 Full Name: FYVE, RhoGEF and PH domain containing 4 Category: mRNA Synonyms: CMT4H|FRABP|ZFYVE6 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 32399529 End Site(bp): 32646050 Gene Summary: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015] External Links: Ensembl ID: ENSG00000139132 HGNC ID: HGNC:19125 Entrez Gene: 121512

Expression Profile of FGD4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p NO YES YES hsa-miR-106b-5p NO YES YES hsa-miR-1-3p YES NO YES hsa-miR-142-5p YES NO YES hsa-miR-17-5p NO YES YES hsa-miR-181a-5p NO YES YES hsa-miR-181b-5p NO YES YES hsa-miR-181c-5p NO YES YES hsa-miR-181d-5p NO YES YES hsa-miR-182-5p NO YES YES hsa-miR-206 YES NO YES hsa-miR-20a-5p NO YES YES hsa-miR-20b-5p NO YES YES hsa-miR-21-5p NO YES YES hsa-miR-218-5p NO YES YES hsa-miR-23a-3p NO YES YES hsa-miR-23b-3p NO YES YES hsa-miR-302a-3p NO YES YES hsa-miR-302b-3p NO YES YES hsa-miR-302c-3p NO YES YES hsa-miR-302d-3p NO YES YES hsa-miR-302e NO YES YES hsa-miR-372-3p NO YES YES hsa-miR-373-3p NO YES YES hsa-miR-519d-3p NO YES YES hsa-miR-520a-3p NO YES YES hsa-miR-520b NO YES YES hsa-miR-520c-3p NO YES YES hsa-miR-520d-3p NO YES YES hsa-miR-520e NO YES YES hsa-miR-590-5p NO YES YES hsa-miR-613 YES NO YES hsa-miR-93-5p NO YES YES Display: