ctcRbase

Entry Detail

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General Information

Database ID: SKCM04825 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SMG7 Full Name: SMG7, nonsense mediated mRNA decay factor Category: mRNA Synonyms: C1orf16|EST1C|SGA56M Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 183472216 End Site(bp): 183598246 Gene Summary: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011] External Links: Ensembl ID: ENSG00000116698 HGNC ID: HGNC:16792 Entrez Gene: 9887

Expression Profile of SMG7 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-1-3p YES YES YES hsa-miR-141-3p YES YES YES hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-185-5p YES YES YES hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-200a-3p YES YES YES hsa-miR-205-5p YES YES NO hsa-miR-206 YES YES YES hsa-miR-22-3p YES YES YES hsa-miR-28-5p YES YES NO hsa-miR-296-5p YES NO YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-330-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-613 YES YES YES hsa-miR-708-5p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-873-5p YES YES NO Display: