ctcRbase

Entry Detail

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General Information

Database ID: SKCM04857 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: BRCC3 Full Name: BRCA1/BRCA2-containing complex subunit 3 Category: mRNA Synonyms: BRCC36|C6.1A|CXorf53 Chromosome: chrX Strand: + Coordinate: Start Site(bp): 155071420 End Site(bp): 155123074 Gene Summary: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011] External Links: Ensembl ID: ENSG00000185515 HGNC ID: HGNC:24185 Entrez Gene: 79184

Expression Profile of BRCC3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-126-5p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-144-3p YES YES YES hsa-miR-145-5p YES YES YES hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-421 YES YES NO Display: