ctcRbase

Entry Detail

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General Information

Database ID: SKCM04868 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: FADD Full Name: Fas associated via death domain Category: mRNA Synonyms: GIG3|MORT1 Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 70203163 End Site(bp): 70207390 Gene Summary: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000168040 HGNC ID: HGNC:3573 Entrez Gene: 8772

Expression Profile of FADD Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-28-5p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-361-5p YES YES YES hsa-miR-370-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-708-5p YES YES NO Display: