ctcRbase

Entry Detail

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General Information

Database ID: SKCM04874 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MECP2 Full Name: methyl-CpG binding protein 2 Category: mRNA Synonyms: AUTSX3|MRX16|MRX79|MRXS13|MRXSL|PPMX|RS|RTS|RTT Chromosome: chrX Strand: - Coordinate: Start Site(bp): 154021573 End Site(bp): 154137103 Gene Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] External Links: Ensembl ID: ENSG00000169057 HGNC ID: HGNC:6990 Entrez Gene: 4204

Expression Profile of MECP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES NO YES hsa-miR-106b-5p YES NO YES hsa-miR-124-3p YES NO YES hsa-miR-130a-3p YES NO YES hsa-miR-130b-3p YES NO YES hsa-miR-132-3p YES NO YES hsa-miR-133a-3p YES NO YES hsa-miR-133b YES NO YES hsa-miR-137 YES NO YES hsa-miR-140-3p YES NO YES hsa-miR-147a YES NO NO hsa-miR-148a-3p YES NO YES hsa-miR-148b-3p YES NO YES hsa-miR-152-3p YES NO YES hsa-miR-17-5p YES NO YES hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-205-5p YES NO YES hsa-miR-20a-5p YES NO YES hsa-miR-20b-5p YES NO YES hsa-miR-212-3p YES NO YES hsa-miR-218-5p YES NO YES hsa-miR-22-3p YES NO YES hsa-miR-301a-3p YES NO YES hsa-miR-301b-3p YES NO YES hsa-miR-30a-5p YES NO YES hsa-miR-30b-5p YES NO YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES NO YES hsa-miR-30e-5p YES NO YES hsa-miR-328-3p YES NO YES hsa-miR-329-3p YES NO NO hsa-miR-361-5p YES YES YES hsa-miR-362-3p YES NO NO hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-454-3p YES NO YES hsa-miR-506-3p YES NO YES hsa-miR-519d-3p YES NO YES hsa-miR-520f-3p YES NO YES hsa-miR-625-5p YES NO NO hsa-miR-93-5p YES NO YES Display: