ctcRbase

Entry Detail

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General Information

Database ID: SKCM04886 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ARRB1 Full Name: arrestin beta 1 Category: mRNA Synonyms: ARB1|ARR1 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 75264182 End Site(bp): 75351705 Gene Summary: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011] External Links: Ensembl ID: ENSG00000137486 HGNC ID: HGNC:711 Entrez Gene: 408

Expression Profile of ARRB1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-138-5p YES NO YES hsa-miR-145-5p YES YES NO hsa-miR-187-3p YES YES NO hsa-miR-22-3p YES YES YES hsa-miR-299-3p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-346 YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-7-5p YES NO YES hsa-miR-9-5p YES YES NO Display: