ctcRbase

Entry Detail

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General Information

Database ID: SKCM04912 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SIRT5 Full Name: sirtuin 5 Category: mRNA Synonyms: SIR2L5 Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 13574529 End Site(bp): 13615158 Gene Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010] External Links: Ensembl ID: ENSG00000124523 HGNC ID: HGNC:14933 Entrez Gene: 23408

Expression Profile of SIRT5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-145-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-421 YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-875-5p YES YES NO Display: