ctcRbase

Entry Detail

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General Information

Database ID: SKCM04941 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: FAR1 Full Name: fatty acyl-CoA reductase 1 Category: mRNA Synonyms: MLSTD2|PFCRD|SDR10E1 Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 13668670 End Site(bp): 13732346 Gene Summary: The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015] External Links: Ensembl ID: ENSG00000197601 HGNC ID: HGNC:26222 Entrez Gene: 84188

Expression Profile of FAR1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-143-3p YES YES YES hsa-miR-145-5p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-299-5p YES NO YES hsa-miR-32-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-421 YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-450a-5p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-875-5p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: