ctcRbase

Entry Detail

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General Information

Database ID: SKCM04954 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PSMD3 Full Name: proteasome 26S subunit, non-ATPase 3 Category: mRNA Synonyms: P58|RPN3|S3|TSTA2 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 39980797 End Site(bp): 39997960 Gene Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012] External Links: Ensembl ID: ENSG00000108344 HGNC ID: HGNC:9560 Entrez Gene: 5709

Expression Profile of PSMD3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-182-5p NO YES YES hsa-miR-224-5p YES YES NO hsa-miR-370-3p YES YES NO hsa-miR-625-5p YES NO NO Display: