ctcRbase

Entry Detail

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General Information

Database ID: SKCM05007 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PRKAB1 Full Name: protein kinase AMP-activated non-catalytic subunit beta 1 Category: mRNA Synonyms: AMPK|HAMPKb Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 119667753 End Site(bp): 119681630 Gene Summary: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000111725 HGNC ID: HGNC:9378 Entrez Gene: 5564

Expression Profile of PRKAB1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-137 YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-301a-3p YES NO YES hsa-miR-301b-3p YES YES YES hsa-miR-31-5p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-454-3p YES NO YES hsa-miR-542-3p YES YES YES Display: