ctcRbase

Entry Detail

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General Information

Database ID: SKCM05029 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: KLHL24 Full Name: kelch like family member 24 Category: mRNA Synonyms: DRE1|EBSSH|KRIP6 Chromosome: chr3 Strand: + Coordinate: Start Site(bp): 183635568 End Site(bp): 183684477 Gene Summary: The protein encoded by this gene is a ubiquitin ligase substrate receptor and is regulated by autoubiquitination. Variations in the translation initiation codon of this gene have been found, which result in an N-terminally truncated but more stable protein due to loss of the autoubiquitination function. The more stable mutant protein causes an increased ubiquitin and degradation of keratin 14, which leads to skin fragility and the potentially life-threatening disease epidermolysis bullosa. The encoded protein is also involved in the regulation of kainate receptors. [provided by RefSeq, Mar 2017] External Links: Ensembl ID: ENSG00000114796 HGNC ID: HGNC:25947 Entrez Gene: 54800

Expression Profile of KLHL24 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-183-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-221-3p YES NO YES hsa-miR-222-3p YES NO YES hsa-miR-224-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-342-3p YES NO YES hsa-miR-365a-3p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-448 YES YES NO hsa-miR-496 YES YES YES hsa-miR-506-3p YES NO YES hsa-miR-876-5p YES YES NO Display: