ctcRbase

Entry Detail

---



General Information

Database ID: SKCM05036 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SMC1A Full Name: structural maintenance of chromosomes 1A Category: mRNA Synonyms: CDLS2|DXS423E|SB1.8|SMC1|SMC1L1|SMC1alpha|SMCB Chromosome: chrX Strand: - Coordinate: Start Site(bp): 53374149 End Site(bp): 53422728 Gene Summary: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] External Links: Ensembl ID: ENSG00000072501 HGNC ID: HGNC:11111 Entrez Gene: 8243

Expression Profile of SMC1A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-129-5p YES NO YES hsa-miR-132-3p YES YES NO hsa-miR-142-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-23a-3p YES NO YES hsa-miR-23b-3p YES NO YES hsa-miR-328-3p YES NO YES hsa-miR-330-3p YES NO YES hsa-miR-383-5p YES NO YES hsa-miR-429 YES YES NO hsa-miR-433-3p YES NO YES hsa-miR-489-3p YES NO YES hsa-miR-874-3p YES NO YES hsa-miR-9-5p YES YES YES hsa-miR-98-5p YES YES YES Display: