ctcRbase

Entry Detail

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General Information

Database ID: SKCM05047 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MAPKAPK5 Full Name: mitogen-activated protein kinase-activated protein kinase 5 Category: mRNA Synonyms: MAPKAP-K5|MK-5|MK5|PRAK Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 111841978 End Site(bp): 111902238 Gene Summary: The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012] External Links: Ensembl ID: ENSG00000089022 HGNC ID: HGNC:6889 Entrez Gene: 8550

Expression Profile of MAPKAPK5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-137 YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-186-5p YES YES YES hsa-miR-195-5p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-381-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-503-5p YES YES NO Display: