ctcRbase

Entry Detail

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General Information

Database ID: SKCM05081 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CDKN2C Full Name: cyclin dependent kinase inhibitor 2C Category: mRNA Synonyms: INK4C|p18|p18-INK4C Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 50960745 End Site(bp): 50974633 Gene Summary: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000123080 HGNC ID: HGNC:1789 Entrez Gene: 1031

Expression Profile of CDKN2C Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-93-5p YES YES NO Display: