ctcRbase

Entry Detail

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General Information

Database ID: SKCM05110 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ARNT2 Full Name: aryl hydrocarbon receptor nuclear translocator 2 Category: mRNA Synonyms: WEDAS|bHLHe1 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 80404350 End Site(bp): 80597937 Gene Summary: This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013] External Links: Ensembl ID: ENSG00000172379 HGNC ID: HGNC:16876 Entrez Gene: 9915

Expression Profile of ARNT2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-23a-3p YES NO YES hsa-miR-23b-3p YES NO YES hsa-miR-299-3p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-543 YES YES YES hsa-miR-873-5p YES YES NO Display: