ctcRbase

Entry Detail

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General Information

Database ID: SKCM05111 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: HARS2 Full Name: histidyl-tRNA synthetase 2, mitochondrial Category: mRNA Synonyms: HARSL|HARSR|HO3|HisRS|PRLTS2 Chromosome: chr5 Strand: + Coordinate: Start Site(bp): 140691426 End Site(bp): 140699291 Gene Summary: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] External Links: Ensembl ID: ENSG00000112855 HGNC ID: HGNC:4817 Entrez Gene: 23438

Expression Profile of HARS2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-497-5p YES YES NO Display: