ctcRbase

Entry Detail

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General Information

Database ID: SKCM05128 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: BMPR1A Full Name: bone morphogenetic protein receptor type 1A Category: mRNA Synonyms: 10q23del|ACVRLK3|ALK3|CD292|SKR5 Chromosome: chr10 Strand: + Coordinate: Start Site(bp): 86756601 End Site(bp): 86932838 Gene Summary: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000107779 HGNC ID: HGNC:1076 Entrez Gene: 657

Expression Profile of BMPR1A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-139-5p YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-143-3p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-186-5p YES YES YES hsa-miR-204-5p YES YES YES hsa-miR-211-5p YES YES YES hsa-miR-25-3p YES NO YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-32-5p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-363-3p YES NO YES hsa-miR-367-3p YES NO YES hsa-miR-410-3p YES NO YES hsa-miR-448 YES YES NO hsa-miR-92a-3p YES NO YES hsa-miR-92b-3p YES NO YES hsa-miR-98-5p YES NO YES Display: