ctcRbase

Entry Detail

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General Information

Database ID: SKCM05188 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: UBE3B Full Name: ubiquitin protein ligase E3B Category: mRNA Synonyms: BPIDS|KOS Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 109477402 End Site(bp): 109536705 Gene Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012] External Links: Ensembl ID: ENSG00000151148 HGNC ID: HGNC:13478 Entrez Gene: 89910

Expression Profile of UBE3B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p NO YES YES hsa-miR-106b-5p NO YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-17-5p NO YES YES hsa-miR-186-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-191-5p YES YES NO hsa-miR-20a-5p NO YES YES hsa-miR-20b-5p NO YES YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-329-3p YES YES NO hsa-miR-335-5p YES YES YES hsa-miR-362-3p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-519d-3p NO YES YES hsa-miR-93-5p NO YES YES Display: