ctcRbase

Entry Detail

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General Information

Database ID: SKCM05196 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: STAT5B Full Name: signal transducer and activator of transcription 5B Category: mRNA Synonyms: STAT5 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 42199168 End Site(bp): 42276707 Gene Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000173757 HGNC ID: HGNC:11367 Entrez Gene: 6777

Expression Profile of STAT5B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-100-5p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-134-5p YES YES YES hsa-miR-141-3p YES NO YES hsa-miR-153-3p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-194-5p YES NO YES hsa-miR-200a-3p YES NO YES hsa-miR-218-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-24-3p YES YES NO hsa-miR-329-3p YES NO NO hsa-miR-340-5p YES YES YES hsa-miR-362-3p YES NO NO hsa-miR-496 YES YES YES hsa-miR-758-3p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-99a-5p YES YES NO hsa-miR-99b-5p YES YES NO Display: