| ncRNA Symbol: | TFIP11 |
| Full Name: | tuftelin interacting protein 11 |
| Category: | mRNA |
| Synonyms: | NTR1|STIP|STIP-1|Spp382|TIP39|bK445C9.6 |
| Chromosome: | chr22 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 26491225 | End Site(bp): | 26512505 |
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| Gene Summary: | This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] |
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