ctcRbase

Entry Detail

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General Information

Database ID: SKCM05215 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TAB3 Full Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 3 Category: mRNA Synonyms: MAP3K7IP3|NAP1 Chromosome: chrX Strand: - Coordinate: Start Site(bp): 30827442 End Site(bp): 30975084 Gene Summary: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000157625 HGNC ID: HGNC:30681 Entrez Gene: 257397

Expression Profile of TAB3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-182-5p YES YES NO hsa-miR-183-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-21-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-448 YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-590-5p YES YES NO Display: