ctcRbase

Entry Detail

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General Information

Database ID: SKCM05228 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DENND5A Full Name: DENN domain containing 5A Category: mRNA Synonyms: EIEE49|RAB6IP1 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 9138825 End Site(bp): 9265390 Gene Summary: This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. [provided by RefSeq, Feb 2017] External Links: Ensembl ID: ENSG00000184014 HGNC ID: HGNC:19344 Entrez Gene: 23258

Expression Profile of DENND5A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES NO hsa-miR-138-5p NO YES NO hsa-miR-147a YES NO NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-24-3p YES YES NO hsa-miR-338-3p YES YES NO hsa-miR-369-3p YES NO NO hsa-miR-370-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-429 YES YES YES hsa-miR-455-3p YES NO YES hsa-miR-542-3p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-96-5p YES YES NO Display: