ctcRbase

Entry Detail

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General Information

Database ID: SKCM05313 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MVK Full Name: mevalonate kinase Category: mRNA Synonyms: LRBP|MK|MVLK|POROK3 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 109573255 End Site(bp): 109598117 Gene Summary: This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] External Links: Ensembl ID: ENSG00000110921 HGNC ID: HGNC:7530 Entrez Gene: 4598

Expression Profile of MVK Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-93-5p YES YES NO Display: