ctcRbase

Entry Detail

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General Information

Database ID: SKCM05385 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DNAJB4 Full Name: DnaJ heat shock protein family (Hsp40) member B4 Category: mRNA Synonyms: DNAJW|DjB4|HLJ1 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 77979175 End Site(bp): 78017964 Gene Summary: The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] External Links: Ensembl ID: ENSG00000162616 HGNC ID: HGNC:14886 Entrez Gene: 11080

Expression Profile of DNAJB4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-100-5p YES YES NO hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-140-5p YES NO YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-183-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES YES hsa-miR-188-5p YES NO YES hsa-miR-194-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-204-5p YES YES YES hsa-miR-211-5p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-299-5p YES NO YES hsa-miR-340-5p YES NO YES hsa-miR-361-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-448 YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-505-3p YES YES NO hsa-miR-876-5p YES YES YES hsa-miR-99a-5p YES YES NO hsa-miR-99b-5p YES YES NO Display: