ctcRbase

Entry Detail

---



General Information

Database ID: SKCM05585 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ITCH Full Name: itchy E3 ubiquitin protein ligase Category: mRNA Synonyms: ADMFD|AIF4|AIP4|NAPP1 Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 34363235 End Site(bp): 34511393 Gene Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] External Links: Ensembl ID: ENSG00000078747 HGNC ID: HGNC:13890 Entrez Gene: 83737

Expression Profile of ITCH Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-216a-5p YES NO YES hsa-miR-216b-5p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-300 YES YES YES hsa-miR-330-3p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-346 YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-379-5p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-410-3p YES YES YES hsa-miR-421 YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-7-5p YES YES YES hsa-miR-93-5p YES YES YES Display: