ctcRbase

Entry Detail

---



General Information

Database ID: SKCM05592 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: STRADB Full Name: STE20 related adaptor beta Category: mRNA Synonyms: ALS2CR2|CALS-21|ILPIP|ILPIPA|PAPK|PRO1038 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 201387858 End Site(bp): 201480846 Gene Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] External Links: Ensembl ID: ENSG00000082146 HGNC ID: HGNC:13205 Entrez Gene: 55437

Expression Profile of STRADB Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-107 YES YES NO hsa-miR-1297 YES YES NO hsa-miR-149-5p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-24-3p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-429 YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-93-5p YES YES NO Display: