ctcRbase

Entry Detail

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General Information

Database ID: SKCM05631 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PTPRF Full Name: protein tyrosine phosphatase, receptor type F Category: mRNA Synonyms: BNAH2|LAR Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 43525187 End Site(bp): 43623666 Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000142949 HGNC ID: HGNC:9670 Entrez Gene: 5792

Expression Profile of PTPRF Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1224-5p YES NO YES hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-132-3p YES YES NO hsa-miR-135a-5p YES NO YES hsa-miR-135b-5p YES NO YES hsa-miR-139-5p YES YES YES hsa-miR-193a-3p YES NO YES hsa-miR-193b-3p YES NO YES hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-212-3p YES YES NO hsa-miR-24-3p YES YES YES hsa-miR-28-5p YES NO YES hsa-miR-299-5p YES NO YES hsa-miR-323a-3p YES NO YES hsa-miR-328-3p YES YES YES hsa-miR-431-5p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-501-3p YES NO YES hsa-miR-502-3p YES NO YES hsa-miR-542-3p YES YES NO hsa-miR-708-5p YES NO YES hsa-miR-760 YES NO YES Display: