ctcRbase

Entry Detail

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General Information

Database ID: SKCM05633 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TLE3 Full Name: TLE family member 3, transcriptional corepressor Category: mRNA Synonyms: ESG|ESG3|GRG3|HsT18976 Chromosome: chr15 Strand: - Coordinate: Start Site(bp): 70047790 End Site(bp): 70098176 Gene Summary: This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013] External Links: Ensembl ID: ENSG00000140332 HGNC ID: HGNC:11839 Entrez Gene: 7090

Expression Profile of TLE3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-326 YES NO YES hsa-miR-338-3p YES YES NO hsa-miR-339-5p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-499a-5p YES YES NO Display: