ctcRbase

Entry Detail

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General Information

Database ID: SKCM05703 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RTTN Full Name: rotatin Category: mRNA Synonyms: MSSP Chromosome: chr18 Strand: - Coordinate: Start Site(bp): 70003031 End Site(bp): 70205945 Gene Summary: This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013] External Links: Ensembl ID: ENSG00000176225 HGNC ID: HGNC:18654 Entrez Gene: 25914

Expression Profile of RTTN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-98-5p YES YES NO Display: