ctcRbase

Entry Detail

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General Information

Database ID: SKCM05779 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: FBXW2 Full Name: F-box and WD repeat domain containing 2 Category: mRNA Synonyms: FBW2|Fwd2|Md6 Chromosome: chr9 Strand: - Coordinate: Start Site(bp): 120751978 End Site(bp): 120793412 Gene Summary: F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000119402 HGNC ID: HGNC:13608 Entrez Gene: 26190

Expression Profile of FBXW2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-146a-5p YES NO YES hsa-miR-146b-5p YES NO YES hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES NO YES hsa-miR-200c-3p YES NO YES hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-219a-5p YES NO YES hsa-miR-223-3p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-331-3p YES NO YES hsa-miR-376c-3p YES NO YES hsa-miR-429 YES NO YES hsa-miR-452-5p YES NO YES hsa-miR-543 YES YES NO hsa-miR-615-3p YES NO YES hsa-miR-7-5p YES NO YES hsa-miR-876-5p YES NO YES hsa-miR-9-5p YES NO YES Display: