ctcRbase

Entry Detail

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General Information

Database ID: SKCM05797 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CHMP4B Full Name: charged multivesicular body protein 4B Category: mRNA Synonyms: C20orf178|CHMP4A|CTPP3|CTRCT31|SNF7|SNF7-2|Shax1|VPS32B|Vps32-2|dJ553F4.4 Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 33811304 End Site(bp): 33854366 Gene Summary: This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009] External Links: Ensembl ID: ENSG00000101421 HGNC ID: HGNC:16171 Entrez Gene: 128866

Expression Profile of CHMP4B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-497-5p YES YES NO hsa-miR-543 YES YES NO hsa-miR-876-5p YES YES NO Display: