ctcRbase

Entry Detail

---



General Information

Database ID: SKCM05801 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MYC Full Name: MYC proto-oncogene, bHLH transcription factor Category: mRNA Synonyms: MRTL|MYCC|bHLHe39|c-Myc Chromosome: chr8 Strand: + Coordinate: Start Site(bp): 127735434 End Site(bp): 127741434 Gene Summary: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000136997 HGNC ID: HGNC:7553 Entrez Gene: 4609

Expression Profile of MYC Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-599 YES YES NO Display: