| ncRNA Symbol: | BRAF | | Full Name: | B-Raf proto-oncogene, serine/threonine kinase | | Category: | mRNA | | Synonyms: | B-RAF1|B-raf|BRAF1|NS7|RAFB1 | | Chromosome: | chr7 | | Strand: | - | | Coordinate: | | Start Site(bp): | 140719327 | End Site(bp): | 140924764 |
| | Gene Summary: | This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017] | | External Links: | |
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