ctcRbase

Entry Detail

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General Information

Database ID: SKCM05848 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: FGF2 Full Name: fibroblast growth factor 2 Category: mRNA Synonyms: BFGF|FGF-2|FGFB|HBGF-2 Chromosome: chr4 Strand: + Coordinate: Start Site(bp): 122826708 End Site(bp): 122898236 Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000138685 HGNC ID: HGNC:3676 Entrez Gene: 2247

Expression Profile of FGF2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO YES hsa-miR-107 YES NO YES hsa-miR-129-5p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-148a-3p YES NO YES hsa-miR-148b-3p YES NO YES hsa-miR-152-3p YES NO YES hsa-miR-154-5p YES YES NO hsa-miR-155-5p YES NO YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-186-5p YES YES YES hsa-miR-190a-5p YES YES YES hsa-miR-190b YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-25-3p YES YES NO hsa-miR-299-3p YES NO YES hsa-miR-32-5p YES YES NO hsa-miR-340-5p YES NO YES hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-496 YES NO YES hsa-miR-497-5p YES YES YES hsa-miR-499a-5p YES YES NO hsa-miR-503-5p YES NO YES hsa-miR-653-5p YES YES NO hsa-miR-665 YES NO YES hsa-miR-876-5p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: