ctcRbase

Entry Detail

---



General Information

Database ID: SKCM05857 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SHC1 Full Name: SHC adaptor protein 1 Category: mRNA Synonyms: SHC|SHCA Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 154962298 End Site(bp): 154974395 Gene Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] External Links: Ensembl ID: ENSG00000160691 HGNC ID: HGNC:10840 Entrez Gene: 6464

Expression Profile of SHC1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-134-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-200b-3p YES NO YES hsa-miR-200c-3p YES NO YES hsa-miR-204-5p YES YES YES hsa-miR-211-5p YES YES YES hsa-miR-218-5p YES YES YES hsa-miR-219a-5p YES YES YES hsa-miR-299-3p YES YES NO hsa-miR-324-5p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-429 YES NO YES hsa-miR-448 YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-665 YES NO YES hsa-miR-873-5p YES YES NO hsa-miR-9-5p YES YES YES hsa-miR-96-5p YES YES YES Display: