ctcRbase

Entry Detail

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General Information

Database ID: SKCM05911 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GCLC Full Name: glutamate-cysteine ligase catalytic subunit Category: mRNA Synonyms: GCL|GCS|GLCL|GLCLC Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 53497341 End Site(bp): 53616970 Gene Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010] External Links: Ensembl ID: ENSG00000001084 HGNC ID: HGNC:4311 Entrez Gene: 2729

Expression Profile of GCLC Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-133a-3p YES NO YES hsa-miR-133b YES NO YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-18a-5p YES YES YES hsa-miR-18b-5p YES YES YES hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-206 YES YES YES hsa-miR-216b-5p YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-543 YES YES NO hsa-miR-613 YES YES YES Display: