ctcRbase

Entry Detail

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General Information

Database ID: SKCM06128 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: IL6ST Full Name: interleukin 6 signal transducer Category: mRNA Synonyms: CD130|CDW130|GP130|IL-6RB Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 55935095 End Site(bp): 55994993 Gene Summary: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014] External Links: Ensembl ID: ENSG00000134352 HGNC ID: HGNC:6021 Entrez Gene: 3572

Expression Profile of IL6ST Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p YES YES NO hsa-miR-129-5p YES NO YES hsa-miR-1297 YES YES NO hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-135a-5p YES NO YES hsa-miR-135b-5p YES NO YES hsa-miR-1-3p YES YES YES hsa-miR-142-3p YES YES YES hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-192-5p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-205-5p YES YES YES hsa-miR-206 YES YES YES hsa-miR-215-5p YES YES YES hsa-miR-219a-5p YES YES NO hsa-miR-223-3p YES YES YES hsa-miR-22-3p YES YES NO hsa-miR-224-5p YES YES YES hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-27a-3p YES NO YES hsa-miR-27b-3p YES NO YES hsa-miR-296-3p YES YES NO hsa-miR-329-3p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES YES hsa-miR-378a-3p YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-421 YES YES YES hsa-miR-422a YES YES NO hsa-miR-429 YES YES YES hsa-miR-452-5p YES NO YES hsa-miR-494-3p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-520f-3p YES NO YES hsa-miR-532-5p YES NO YES hsa-miR-613 YES YES YES hsa-miR-668-3p YES NO YES hsa-miR-758-3p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-9-5p YES NO YES Display: