ctcRbase

Entry Detail

---



General Information

Database ID: SKCM06197 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DERL1 Full Name: derlin 1 Category: mRNA Synonyms: DER-1|DER1|derlin-1 Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 123013164 End Site(bp): 123042423 Gene Summary: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012] External Links: Ensembl ID: ENSG00000136986 HGNC ID: HGNC:28454 Entrez Gene: 79139

Expression Profile of DERL1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-132-3p YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-182-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-223-3p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-324-5p YES YES NO hsa-miR-328-3p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-384 YES YES NO hsa-miR-486-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-758-3p YES YES NO hsa-miR-874-3p YES YES NO Display: