| ncRNA Symbol: | PMS1 | | Full Name: | PMS1 homolog 1, mismatch repair system component | | Category: | mRNA | | Synonyms: | HNPCC3|MLH2|PMSL1|hPMS1 | | Chromosome: | chr2 | | Strand: | + | | Coordinate: | | Start Site(bp): | 189784085 | End Site(bp): | 189877629 |
| | Gene Summary: | This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008] | | External Links: | |
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