ctcRbase

Entry Detail

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General Information

Database ID: SKCM06203 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SMARCA4 Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Category: mRNA Synonyms: BAF190|BAF190A|BRG1|CSS4|MRD16|RTPS2|SNF2|SNF2L4|SNF2LB|SWI2|hSNF2b Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 10961001 End Site(bp): 11065395 Gene Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] External Links: Ensembl ID: ENSG00000127616 HGNC ID: HGNC:11100 Entrez Gene: 6597

Expression Profile of SMARCA4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES NO YES hsa-miR-132-3p YES YES NO hsa-miR-139-5p YES YES YES hsa-miR-144-3p YES NO YES hsa-miR-155-5p YES YES YES hsa-miR-191-5p YES YES NO hsa-miR-199a-5p YES NO YES hsa-miR-199b-5p YES NO YES hsa-miR-212-3p YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-7-5p YES YES NO Display: