ctcRbase

Entry Detail

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General Information

Database ID: SKCM06232 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: STAT6 Full Name: signal transducer and activator of transcription 6 Category: mRNA Synonyms: D12S1644|IL-4-STAT|STAT6B|STAT6C Chromosome: chr12 Strand: - Coordinate: Start Site(bp): 57095408 End Site(bp): 57132139 Gene Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] External Links: Ensembl ID: ENSG00000166888 HGNC ID: HGNC:11368 Entrez Gene: 6778

Expression Profile of STAT6 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-150-5p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-486-5p YES YES NO hsa-miR-496 YES YES NO Display: