| ncRNA Symbol: | ALG11 | | Full Name: | ALG11, alpha-1,2-mannosyltransferase | | Category: | mRNA | | Synonyms: | CDG1P|GT8 | | Chromosome: | chr13 | | Strand: | + | | Coordinate: | | Start Site(bp): | 52012398 | End Site(bp): | 52029664 |
| | Gene Summary: | This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010] | | External Links: | |
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