ctcRbase

Entry Detail

---



General Information

Database ID: SKCM06292 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PFKFB3 Full Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Category: mRNA Synonyms: IPFK2|PFK2|iPFK-2 Chromosome: chr10 Strand: + Coordinate: Start Site(bp): 6144934 End Site(bp): 6254644 Gene Summary: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] External Links: Ensembl ID: ENSG00000170525 HGNC ID: HGNC:8874 Entrez Gene: 5209

Expression Profile of PFKFB3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-1271-5p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-150-5p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-185-5p YES NO NO hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-216b-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-300 YES YES YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-320a NO YES YES hsa-miR-320b NO YES YES hsa-miR-320c NO YES YES hsa-miR-320d NO YES YES hsa-miR-335-5p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-346 NO YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-488-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-93-5p YES YES YES hsa-miR-96-5p YES YES NO Display: