ctcRbase

Entry Detail

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General Information

Database ID: SKCM06296 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: STIL Full Name: STIL, centriolar assembly protein Category: mRNA Synonyms: MCPH7|SIL Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 47250139 End Site(bp): 47314147 Gene Summary: This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000123473 HGNC ID: HGNC:10879 Entrez Gene: 6491

Expression Profile of STIL Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-144-3p YES YES YES hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-653-5p YES YES NO Display: