ctcRbase

Entry Detail

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General Information

Database ID: SKCM06334 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: FLRT2 Full Name: fibronectin leucine rich transmembrane protein 2 Category: mRNA Synonyms: - Chromosome: chr14 Strand: + Coordinate: Start Site(bp): 85530144 End Site(bp): 85654426 Gene Summary: This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] External Links: Ensembl ID: ENSG00000185070 HGNC ID: HGNC:3761 Entrez Gene: 23768

Expression Profile of FLRT2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-147a YES NO NO hsa-miR-187-3p YES YES NO hsa-miR-194-5p YES NO YES hsa-miR-216a-5p YES YES NO hsa-miR-218-5p YES NO YES hsa-miR-329-3p YES NO NO hsa-miR-362-3p YES NO NO hsa-miR-496 YES YES YES hsa-miR-543 YES NO YES hsa-miR-653-5p YES YES NO hsa-miR-7-5p YES YES YES Display: