| ncRNA Symbol: | TAP2 | | Full Name: | transporter 2, ATP binding cassette subfamily B member | | Category: | mRNA | | Synonyms: | ABC18|ABCB3|APT2|D6S217E|PSF-2|PSF2|RING11 | | Chromosome: | chr6 | | Strand: | - | | Coordinate: | | Start Site(bp): | 32821833 | End Site(bp): | 32838780 |
| | Gene Summary: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014] | | External Links: | |
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