ctcRbase

Entry Detail

---



General Information

Database ID: SKCM06398 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CFH Full Name: complement factor H Category: mRNA Synonyms: AHUS1|AMBP1|ARMD4|ARMS1|CFHL3|FH|FHL1|HF|HF1|HF2|HUS Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 196651878 End Site(bp): 196747504 Gene Summary: This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011] External Links: Ensembl ID: ENSG00000000971 HGNC ID: HGNC:4883 Entrez Gene: 3075

Expression Profile of CFH Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-28-5p YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-429 YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-708-5p YES YES NO Display: