ctcRbase

Entry Detail

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General Information

Database ID: SKCM06402 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: LZTS2 Full Name: leucine zipper tumor suppressor 2 Category: mRNA Synonyms: LAPSER1 Chromosome: chr10 Strand: + Coordinate: Start Site(bp): 100996618 End Site(bp): 101007836 Gene Summary: The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015] External Links: Ensembl ID: ENSG00000107816 HGNC ID: HGNC:29381 Entrez Gene: 84445

Expression Profile of LZTS2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES YES NO hsa-miR-125b-5p YES YES NO hsa-miR-133a-3p YES NO YES hsa-miR-133b YES NO YES hsa-miR-138-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-300 YES YES YES hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-9-5p YES YES YES Display: